Structure of human TRPM8 channel | Communications Biology
WEBOct 19, 2023 · The cryo-EM structure of a human TRPM8 channel in the closed state is presented with insights into the N-terminal pre-melastatin homology region, lipid binding, and icilin binding.
Chapter 13 TRPM8: The Cold and Menthol Receptor - National …
WEBThis chapter focuses on TRPM8, describing what was known about cold signaling before the channel was cloned, how TRPM8 was identified as a cold sensor, and what advances have been made in our understanding of the molecular logic for …
Evidence that the cold- and menthol-sensing functions of the …
WEBJun 21, 2024 · Transient receptor potential melastatin 8 (TRPM8) is a temperature- and menthol-sensitive ion channel that contributes to diverse physiological roles, including cold sensing and pain perception.
TRPM8 channels: A review of distribution and clinical role
WEBSep 5, 2020 · TRPM8 channels can be found in multiple organs and tissues, regulating several important processes such as cell proliferation, migration and apoptosis, inflammatory reactions, immunomodulatory effects, pain, and vascular muscle tension.
TRPM8-androgen receptor association within lipid rafts …
WEBSep 9, 2019 · Thus, the results of biotinylation assays demonstrate that TRPM8 promotes plasmalemmal localization of the AR, while TST facilitates its withdrawal from the PM.
Molecular mechanisms underlying menthol binding and activation of TRPM8 ...
WEBJul 29, 2020 · Menthol in mints elicits a coolness sensation by selective activation of TRPM8 ion channel. Here authors dock menthol to TRPM8 and systematically validate their menthol binding models with ...
The TRPM8 Protein Is a Testosterone Receptor - PMC
WEBJan 1, 2015 · Along with the sensory neurons, the TRPM8 protein is highly expressed in the prostate epithelial cells, and this expression is regulated by androgens. Here we investigated the expression and intracellular localization of the TRPM8 channel in relationship to androgens.
Lipid Raft Segregation Modulates TRPM8 Channel Activity
WEBHere we show that, in sensory neurons, TRPM8 channel is localized in cholesterol-rich specialized membrane domains known as lipid rafts. We also show that, in heterologous expression systems, lipid raft segregation of TRPM8 is favored by glycosylation at the Asn 934 residue of the polypeptide.
Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and …
WEBJan 16, 2008 · TRPM8 is expressed in nonpeptidergic and IB4-negative small-diameter neurons. To characterize the expression of EGFPf in vivo, we analyzed sections of adult DRG, lumbar spinal cord, and skin from TRPM8EGFPf/+ and TRPM8EGFPf/EGFPf mice either unstained or stained with antibodies against GFP.
Transient Receptor Potential Melastatin 8 (TRPM8)-Based …
WEBMar 29, 2019 · Transient receptor potential melastatin 8 (TRPM8) is a major receptor of cold environment. Recently, we found that cigarette smoke extract (CSE) upregulated TRPM8 mRNA and protein expression in bronchial tissues …
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